
Endodontics
- Our rinsing and cleaning solutions: simple, safe, straight from the bottle into the syringe
- Saves time and material, with virtually no product loss

- With our innovative ESD system

Goodbye stains! Safety for your expensive treatment unit
The ESD system from lege artis, also known as “the removal system for endo solutions”, is an innovative technology. It enables simple, safe and direct dispensing of rinsing and cleaning solutions. There is no need for tedious decanting, stains caused by spillage are avoided and the simple handling saves time and increases endo success – a clean solution!
Five problems of market competitors:
- Cumbersome removal
- Hygiene requirements
- Risk of contamination, stains due to spillage
- Product losses
- Extra system: not integrated
Rinsing with ESD system: simple, safe & direct

1. simply put it on
Open the sealing cap and place the Luer or Luer lock syringe securely on the integrated inlay of the bottle

2. safe mounting
Pull up your desired volume safely

3. direct rinsing
Remove the syringe, close the cap and rinse directly: done!5 solutions from lege artis – simple, safe, straight from the bottle into the syringe:
- Simple, safe and direct drawing up of the solution using Luer/Luer lock syringes
- Hygienic, no contamination, no stains due to spillage
- Saves time and material, with virtually no product loss
- Pouring directly from the bottle is also possible
- Integrated in every bottle


CALCINASE EDTA solution
- Effectively removes smear layer in combination with HISTOLITH NaOCI (1/3/5%)
- Improves the adhesion of later filling materials
- Helps to visualize root canal entrances
- Simplifies the access and preparation
- Guaranteed consistent quality and stability of active substances with proper storage
Yes, it is printed on the folding box (426009703 301 5 / 426009703 332 9 / 426009703 331 2 for 50/200/500 ml).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
3 years from production (see information on label and folding box).
Yes, CALCINASE EDTA solution is available in 50 ml, 200 ml and 500 ml bottles.
CALCINASE EDTA solution contains 20 % sodium edetate.
CALCINASE EDTA solution dissolves the dentin by binding calcium ions and thus facilitates smooth-walled preparation. Sodium edetate is used for acid-free dissolution of dentin for root canal preparation and is used to remove the smear layer, especially in combination with sodium hypochlorite solution.
It can also be used to locate root canals and to remove harmful calcium deposits on instruments.
If CALCINASE EDTA solution is too thin, we recommend the use of an EDTA gel, e.g. CALCINASE-slide (Art. No. 0032319).
Yes, alternatively also CALCINASE-slide (EDTA gel: art. no. 0032319).
Yes, e.g. with HISTOLITH NaOCl 5% (200/500 ml; art. no. 0032120/0032112); HISTOLITH NaOCl 3% (200/500 ml; art. no. 0032339/0032340) or HISTOLITH NaOCl 1% (200/500 ml; art. no. 0032342/0032343) other options must be checked individually).
For allergy to sodium edetate; for wide open apical foramen.
None known when used as intended in the root canal. However, very long exposure times or prolonged rinsing with large amounts of EDTA solution can lead to softening of the root dentin and increased dentin permeability. If the substance reaches the apex, irritation of the periapical tissue is possible.
Yes; thanks to the ESD system incorporated in all bottles, CALCINASE EDTA solution can be drawn directly into a plastic syringe with a Luer or Luer Lock system.
There are no known side effects. Working with a rubber dam.
Yes, it makes mechanical processing easier.
8.4 (mean value; specification: 7.9 – 8.9).
Yes, it is ideally suited and saves laborious probing.
No. Guaranteed consistent quality when stored at up to 30°.
With a disposable syringe and the integrated ESD system.
All commercially available Luer and Luer lock syringes. Pouring is still possible.
Simple, safe, directdispensing: from the bottle into the syringe.
Yes, the innovative ESD system is integrated into every bottle of rinsing solution.
It saves time and material, with virtually no product loss.
Yes, when endodontically treating deciduous teeth, the stage of development and special anatomy must be taken into account.
For effective removal of the smear layer in combination with HISTOLITH NaOCI (1/3/5%) and for better detection and preparation of root canals.
CALCINASE slide
- Expands root canals and easily removes smear layer in combination
with HISTOLITH NaOCl (1/3/5 %) - Reduces the risk of instrument fractures
- Simplifies instrument guidance in obliterated and curved root canals
- Liquefies during preparation

Yes: 4 260097 033190.
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
3 years from production (see information on label and folding box).
For root canal preparation and removal of the smear layer: Simplifies the guidance of the instruments in obliterated and curved root canals.
No, only available in packs of 9 ml tubes.
CALCINASE-slide contains 15% sodium edetate, 15% sodium edetate in a water-soluble gel base.
EDTA dissolves calcium ions from the root canal surface by forming a chelate complex, thus softening the substrate and enabling the removal of the so-called smear-layer (a smear layer created by filing); the gel serves as a lubricant during the use of files and reduces the risk of instrument fractures.
By rinsing with aqueous solutions, e.g. HISTOLITH NaOCl 1%, 3% or 5% or physiologic saline solution. Saline solution.
The thixotropic gel can be temporarily made slightly thinner by shearing (e.g. spatulating).
Yes, it is suitable for both automated and manual processing.
Briefly spatulate the gel, then remove with a dry lentulo or file.
If the cap is accidentally not screwed on tightly or the tube is left open for a long time, or if the expiry date has passed, the gel dries up and becomes unusable; it can be brought back to the desired consistency shortly before use by mixing it with a little water or, better still, with CALCINASE solution.
None are known when used as intended in the root canal; if the gel substance reaches the apex, irritation of the periapical tissue is possible.
In case of allergy to sodium edetate and wide open apical foramen.
No, can be removed and applied directly from the tube.
No, our product liquefies during mechanical processing.
Yes, it can. Our CALCINASE EDTA solution is even better suited for this.

CALICIPRO
CALCIUM hydroxide powder for PROfessionals: Calcium hydroxide powder for direct pulp capping and temporary root canal fillings in the consistency of your choice
- Always fresh and easy to mix with purified water, Physiological saline solution or HISTOLITH NaOCI (1/3/5%)
- Consistency individually determinable : from aqueous suspension to a smooth paste
- Very economical as minimal product is required
- Radioopaque / radiopaque
Contains
- 90 % calcium hydroxide, barium sulfate
- Specialist information (DE,EN,NL,HR,RS,SI,CZ,SK)
- Safety data sheet (EN)
- Summary of Safety and Clinical Performance according to Article 32 MDR (in progress)
Yes, PZN 03672148.
Yes: 4260097033183.
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
3 years from production (see information on label and FS); keep bottle tightly closed.
No, CALCIPRO is only available as a powder. Consistency can be individually mixed fresh: from an aqueous suspension to a smooth paste.
CALCIPRO is radiopaque due to the components it contains; the radiopacity is in the dentin/enamel range. The radiopacity of CALCIPRO enables quality control and increases application safety.
Use a little more liquid and mix a little thinner.
Use a little less liquid or add powder; Possible causes: Expiry date exceeded or left open too long.
Mainly mechanically by filing and residues chemically by rinsing with e.g. CALCINASE EDTA solution (art. no. 0032301, 0032331, 0032332).
For direct capping of the pulp and as a temporary root canal insert.
For capping the pulp and as a temporary root canal insert.
Our freshly mixed calcium hydroxide works consistently well (pH value remains constant for a long time). It only solidifies after mixing and not in the syringe. The consistency can be determined individually: from an aqueous suspension to a smooth paste. CALCIPRO is therefore economical and economical to use.
Gradually add the powder to the liquid until the desired consistency is reached.
Preferably with distilled water; however, direct mixing with sodium hypochlorite solution (e.g. HISTOLITH NaOCl 1%, 3% or 5%) or with chlorhexidine solution has also been reported in the literature.
There are no known contraindications for use, provided that the pulp has been diagnosed as fit for preservation.
No side effects are known when used as directed.
Yes, CALCIPRO is safe to use here due to its composition.
There are no known contraindications.
CHX-Endo 2%
The classic CHX-Solution: 2% Chlorhexidine cleaning solution
- Cleans and reduces the number of germs
- Endo instruments quickly ready for use again during reprocessing (after cleaning)
- Guaranteed consistent quality and stability with proper storage

Yes, is printed on the folding box (200 ml 4 260097 033343; 500 ml 4 260097 033381).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
2 years from production (see information on label and folding box).
Yes; CHX-Endo 2% solution is available in 200 ml and 500 ml bottles.
CHX-Endo 2% solution contains 2 % chlorhexidine digluconate.
CHX-Endo 2% solution cleans the file in the stand or surfaces wetted with the solution thanks to the surfactants it contains.
CHX-Endo 2% has not been tested for this purpose. CHX-containing and NaOCl-containing solutions should not be mixed, as this will result in red-colored precipitates. Mixing EDTA-containing and CHX-containing solutions/gels can also result in a white precipitate or the formation of a second phase.
CHX-Endo 2% has not been tested for this purpose.
The use of pastes made from CHX solutions and calcium hydroxide powders has been described in the literature.
In case of allergy to chlorhexidine or one of the ingredients.
No, CHX-Endo 2% has not been tested for this purpose.
No, CHX-Endo 2% has not been tested for this purpose.
5.5 (mean value; specification: 4.5 – 6.5).
No. Storage at 8-25° Celsius guarantees consistent quality.
2% chlorhexidine cleaning solution cleans and reduces germs. Endo instruments are thus quickly ready for use again during reprocessing.

HERMETIC
HERMETIC root canal sealer: Zinc oxide eugenol sealer for root canal fillings (2 components for individual mixing). HERMETIC is available as a powder and solution.
- Wall-mounted
- Hermetic closure due to expansion while binding
- X-ray visible
- Specialist information (DE,EN,NL,HR,RS,SI,CZ,SK)
- Safety data sheet solution (EN)
- Safety data sheet powder (EN)
- Summary of Safety and Clinical Performance according to Article 32 MDR (in progress)
Yes, is printed on the folding box: HERMETIC 14 g powder: 4 260097 033091 and HERMETIC solution 8 ml 4 260097 033084.
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
Powder and solution each 3 years from production (see information on label and folding box).
You may need to add a little less powder. Note: The absorption of moisture accelerates the setting time of HERMETIC.
You may need to add a little more powder.
Product must be checked by the manufacturer; please return.
5 – 12 minutes.
1 – 2 days. A longer curing time facilitates prompt revision.
Yes; the radiopacity corresponds to approx. 5 – 7 mm or 500 – 700 % aluminum (cf. dentin 100 %, enamel 200 %), but depends on the layer thickness.
Due to the slightly higher solubility of zinc oxide eugenol (ZOE) cements, small amounts of overfilled material are absorbed.
Yes, but partial resorption is possible with an unreinforced ZOE cement, especially for large areas due to the slightly higher solubility.
The ratio is 4:1, i.e. 4x powder, 1x solution.
Ideally timed and mechanical.
Mix and wet gutta-percha sticks with it before obturation.
HISTOLITH NaOCI
The ENDO-solution: 1/3/5% Sodium hypochlorite solution, solution for rinsing, cleaning and disinfecting root canals
- Disinfects root canals
- Dissolves necrotic tissue residues
- Removes smear layer in combination with CALCINASE EDTA solution
- Guaranteed consistent quality and stability of active substances with proper storage
- Optimal with ultrasonic activation (HISTOLITH NaOCI 1%)
All information about the HISTOLITH NaOCI 1%
Yes is printed on the folding box PZN 12472649 / PZN 12472655 (200 / 500 ml).
Yes, 426009703 342 8 / 426009703 343 5 (200 / 500 ml).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
Store upright, only in the original containers. HISTOLITH NaOCl 1% 200 ml has a shelf life of 2 years and HISTOLITH NaOCl 1% 500 ml has a shelf life of 3 years (unopened, stored at 2 – 25 °C). The shelf life after opening the bottle is 6 months.
No, HISTOLITH NaOCl 1% does not require a cold chain.
The container must always be kept tightly closed, otherwise the NaOCl concentration is likely to drop.
Described in the literature to increase effectiveness. If heating is used, only the required quantity (e.g. a previously filled syringe) should be heated as briefly and quickly as possible and the solution should be used immediately afterwards, as the content then decreases rapidly due to the activation of the solution.
Described in the literature to increase effectiveness. If ultrasound is used, this should take place directly in the canal, as the content then decreases rapidly due to the activation of the solution.
Yes; thanks to the ESD system incorporated in all bottles, HISTOLITH NaOCl 1% can be aspirated directly into a plastic syringe with a Luer or Luer Lock system.
Yes; alternate rinsing with EDTA is recommended.
Yes; HISTOLITH NaOCl 3% and HISTOLITH NaOCl 5%.
It is an indication that HISTOLITH NaOCl contains 1% sodium hypochlorite (NaOCl). The percentage refers to the amount of active chlorine in mg per ml (m/V).
No, HISTOLITH NaOCl 1% is not suitable for this.
HISTOLITH NaOCl 1% is not intended for this area of application. There are indications in the literature that diluted NaOCl solutions (<1%) have already been used for pocket irrigation.
Rinse immediately with plenty of water. Rinsing with an eye wash bottle is ideal. If necessary (and for additional safety), consult a doctor or ophthalmologist afterwards.
1 % m/V active chlorine corresponds to 1.05 % m/V NaOCl.
Depending on the density of the solution. This is approximately 1.02 g/ml. Thus 1.05 % m/V NaOCl in about 1.0 % m/m (or % by weight) NaOCl. Conversely, 1 % by weight is approximately 1.0 % m/V.
Products containing chlorhexidine should not be combined directly with products containing NaOCl, such as HISTOLITH NaOCl 1%, as this would result in an undesirable, poorly soluble red precipitate. Sufficient intermediate rinsing must always be carried out.
approx. 12 (specification: 11.0 – 13.0).
For allergy to chlorine; for open apical foramen.
No side effects are known when used as intended in the root canal. If sodium hypochlorite reaches the apex, irritation of the periapical tissue is possible. HISTOLITH NaOCl 1% has an irritating effect on healthy tissue.
If the root canal is first rinsed with an EDTA solution and then cleaned with HISTOLITH NaOCl 1%, the smear layer created during preparation can be removed with this combination.
No, storage at below 25° Celsius guarantees consistent quality.
With a disposable syringe and the integrated ESD system.
All commercially available Luer and Luer lock syringes. Pouring is still possible.
Simple, safe, directdispensing: from the bottle into the syringe.
Yes, the innovative ESD system is integrated into every bottle of rinsing solution.
It saves time and material, with virtually no product loss.
Solution for dental use: As an irrigation solution for cleaning the root canal.
All information about the HISTOLITH NaOCI 3%
Yes is printed on the folding box PZN 10832687/ PZN 10832693 (200/500 ml).
Yes, 4 260097 033398 / 4 260097 033404 (200 / 500 ml).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
Store upright, only in the original containers HISTOLITH NaOCl 3% has a shelf life of 3 years (unopened, stored at 2 – 8 °C). The shelf life after opening the bottle is 6 months.
HISTOLITH NaOCl 3% does not require cold chain storage. Based on the available data and experience, HISTOLITH NaOCl 3% can be stored and transported at 25 °C for a maximum of one month and at 40 °C for a maximum of 7 days without any loss of quality. In practice, the bottle can be removed from the refrigerator several times for use.
The container must always be kept tightly closed, otherwise the NaOCl concentration is likely to drop.
Described in the literature to increase effectiveness. If heating is used, only the required quantity (e.g. a previously filled syringe) should be heated as briefly and quickly as possible and the solution should be used immediately afterwards, as the content then decreases rapidly due to the activation of the solution.
Described in the literature to increase effectiveness. If ultrasound is used, this should take place directly in the canal, as the content then decreases rapidly due to the activation of the solution.
Yes; thanks to the ESD system incorporated in all bottles, HISTOLITH NaOCl 3% can be aspirated directly into a plastic syringe with a Luer or Luer Lock system.
Yes; alternate rinsing with EDTA is recommended.
Yes; HISTOLITH NaOCl 1% and HISTOLITH NaOCl 5%.
It is an indication that HISTOLITH NaOCl contains 3% sodium hypochlorite (NaOCl). The percentage refers to the amount of active chlorine in mg per ml (m/V).
No, HISTOLITH NaOCl 3% is not suitable for this.
HISTOLITH NaOCl 3% is not intended for this area of application. There are indications in the literature that diluted NaOCl solutions (<1%) have already been used for pocket irrigation.
Rinse immediately with plenty of water. Rinsing with an eye wash bottle is ideal. If necessary (and for additional safety), consult a doctor or ophthalmologist afterwards.
3 % m/V active chlorine corresponds to 3.15 % m/V NaOCl.
Depending on the density of the solution. This is about 1.06 g/ml. Thus 3.15 % m/V NaOCl in about 3.0 % m/m (or % by weight) NaOCl. Conversely, 3 % by weight is about 3.2 % m/V.
Products containing chlorhexidine should not be combined directly with products containing NaOCl, such as HISTOLITH NaOCl 3%, as this would result in an undesirable, poorly soluble red precipitate. Sufficient intermediate rinsing must always be carried out.
approx. 12 (specification: 11.0 – 13.0).
For allergy to chlorine; for open apical foramen.
No side effects are known when used as intended in the root canal. If sodium hypochlorite reaches the apex, irritation of the periapical tissue is possible. HISTOLITH NaOCl 3% has an irritating effect on healthy tissue.
If the root canal is first rinsed with an EDTA solution and then cleaned with HISTOLITH NaOCl 3%, the smear layer created during preparation can be removed with this combination.
Rinse the oral cavity with plenty of water and drink lots of water.
Yes, storage at 2-8° Celsius guarantees consistent quality.
With a disposable syringe and the integrated ESD system.
All commercially available Luer and Luer lock syringes. Pouring is still possible.
Simple, safe, directdispensing: from the bottle into the syringe.
Yes, the innovative ESD system is integrated into every bottle of rinsing solution.
It saves time and material, with virtually no product loss.
Solution for dental use: As an irrigation solution for cleaning and disinfecting the root canal.
All information about the HISTOLITH NaOCI 5%
Yes, distribution via dental wholesalers is also permitted.
Yes is printed on the folding box PZN 04869539 / PZN 05377850 (200 / 500 ml).
Yes, 4 260097 031202 / 4 260097 031127 (200 / 500 ml).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
HISTOLITH NaOCl 5% is stable for 3 years from the date of manufacture in the unopened container. HISTOLITH NaOCl 5% is stable for 6 months after opening. Store upright, only in the original containers.
HISTOLITH NaOCl 5% does not require cold chain storage, storage at 2-8° C.
Storage at higher temperatures: e.g. 25° degrees reduces the shelf life by reducing the concentration of the active ingredient.
Contamination: Do not insert anything into the bottle (pipette, syringe needle etc., especially no metal objects) but pour around it! It is easier and safer to fill plastic syringes directly with the integrated ESD system. This can extend the shelf life after opening.
Storage method: Only store in the original container (in the dark) at 2-8° C, as light also has a negative effect on stability.
Activation by heat or ultrasound: can only be used for a short time afterwards, as the concentration is greatly reduced by activation.
Described in the literature as a short-term increase in effectiveness. If heating is used, only the required quantity (e.g. a previously filled syringe) should be heated as briefly and quickly as possible and the solution should be used immediately afterwards, as the content then decreases rapidly due to the activation of the solution.
Described in the literature as a short-term increase in effectiveness. If heating is used, only the required quantity (e.g. a previously filled syringe) should be heated as briefly and quickly as possible and the solution should be used immediately afterwards, as the content then decreases rapidly due to the activation of the solution.
Yes; thanks to the ESD system incorporated in all storage bottles, HISTOLITH NaOCl 5% can be drawn directly into a plastic syringe with a Luer or Luer Lock system.
Yes, but this is unnecessary as HISTOLITH NaOCl from lege artis is also available in other concentrations such as 3% and 1%.
No, except for mixing CALCIPRO (calcium hydroxide powder).
Yes; alternate rinsing with EDTA is recommended.
Yes, HISTOLITH NaOCl 1% and HISTOLITH NaOCl 3%.
Disinfects and dissolves organic tissue.
No, HISTOLITH NaOCl 5% is not suitable for this.
HISTOLITH NaOCl 5% is not approved for this area of application. There is evidence from the literature that diluted NaOCl solutions (<1%) have also been used for pocket irrigation.
Rinse immediately with plenty of water. Rinsing with an eye wash bottle is ideal. If necessary (and for additional safety), consult a doctor or ophthalmologist afterwards.
It is an indication that HISTOLITH NaOCl contains 5% sodium hypochlorite (NaOCl). The percentage refers to the amount of active chlorine in mg per ml (m/V).
5 % m/V active chlorine corresponds to 5.25 % m/V NaOCl.
approx. 12 (specification: 11.0 – 13.0).
Rinse the oral cavity with plenty of water and drink lots of water.
Yes, storage at 2-8° Celsius guarantees consistent quality.
With a disposable syringe and the integrated ESD system.
All commercially available Luer and Luer lock syringes. Pouring is still possible.
Simple, safe, directdispensing: from the bottle into the syringe.
Yes, the innovative ESD system is integrated into every bottle of rinsing solution.
It saves time and material, with virtually no product loss.
Solution for dental use: As an irrigation solution for cleaning and disinfecting the root canal.
Special care should be taken with children.
Products containing chlorhexidine should not be combined directly with products containing NaOCl, such as HISTOLITH NaOCl 5%, as this would result in an undesirable, poorly soluble red precipitate. Sufficient intermediate rinsing must always be carried out.
For allergy to chlorine; for open apical foramen.
HISTOLITH NaOCl 5% is highly corrosive to living tissue. If used incorrectly (e.g. pressing the solution beyond the apex), the tissue-dissolving effect of sodium hypochlorite can cause damage to living tissue that comes into contact with the rinsing solution. These are usually, but not always, reversible. The following side effects have been observed (frequency unknown): Hypersensitivity reactions, including swelling of the face and mouth, edema, inflammation, ulceration, necrosis, ecchymosis, pain, paresthesia and anesthesia of affected facial nerves. Warning: Caution, corrosive! Status: 10/2014
ID: Medicinal product (Registration number 6030426.00.00)
HISTOLITH NaOCl 5% Dental Solution Active ingredient: Sodium hypochlorite. 1 ml of solution contains 52.5 mg (5.25 % m/V) sodium hypochlorite corresponding to 50 mg (5.0 % m/V) active chlorine. Additives: Sodium chloride, sodium hydroxide and purified water. Indications: For cleaning and disinfection of root canals. Contraindications: Hypersensitivity to the active substance or any other ingredients or chlorine; open apical foramen. Side Effects: On vital tissue HISTOLITH NaOCl 5% effects highly caustic. In case of an inappropriate application (e.g. pressing the solution through the apex) this, because of its tissue-dissolving properties, may cause damages on vital tissue which comes in contact with NaOCl. Mostly, but not in every case, this damages are reversible. The following side effects have been reported (frequency not known): hypersensitivity, including swelling of face or mouth, oedema, inflammation, ulceration, necrosis, ecchymosis, pain, paresthesia and anesthesia affected facial nerves. Precautions: Caution, caustic. Date of current information: 09/2019 lege artis Pharma GmbH + Co. KG, P. O. Box 60, D-72132 Dettenhausen
Rinsing protocol: safe and effective rinsing
Having control over processes is everything, especially in the supreme discipline of endodontics. In the endodontic irrigation protocols provided for clients, lege artis Pharma shows how to irrigate efficiently and carry out root canal treatment successfully. Particularly noteworthy are the recommendations by Prof. Dr. Michael Hülsmann (working at the University of Göttingen until 2021). As an endodontic expert, he contributed his knowledge to this detailed practical guide after more than 40 years of experience as a dentist and scientist.
The irrigation protocols make it clear that mechanical root canal preparation alone is not sufficient to reduce bacteria. They explain which irrigation solutions contribute to the reduction of bacteria and removal of the smear layer. Prof. Dr. Hülsmann shows which rinsing solutions are indicated for pulpitis, necrosis or revision and when sodium hypochlorite, chlorhexidine digluconate and EDTA are used. Skillful, Endodont!

Endodontic irrigation protocols
You can download our endodontic irrigation protocols here.
TOXAVIT
The last resort: Paraformaldehyde paste for devitalizing the dental pulp
- In particular cases of emergency & strong pain treatment where endodontic surgical measures (e.g. vital extirpation) are not possible anymore
- Contains an anaesthetic that quickly relieves pain before devitalization sets in
- Easy to apply and safe to remove/extirpate in toto: Tough, compact, homogeneous and non-crumbling consistency with color contrast (dark grey)
Contains, among other things:
- Lidocaine
- Eugenol

Yes; may also be billable as an analgesic.
Yes, it is printed on the folding box (4 260097 031196).
Yes, available as a service from lege artis: in German and English (available as a PDF file at “www.legeartis.de”).
You can find all the latest publications and information about our products on our website: www.legeartis.de. We always provide you with the latest content there.
In the intact container 2 years from the date of manufacture (see information on label and folding box) after opening TOXAVIT must be used within 6 months.
No; for TOXAVIT, based on the available data and experience, an interruption of refrigeration (transportation) of a maximum of 3 days at a maximum of 30° degrees can be assumed without any loss of quality; short-term removal from the refrigerator for the respective use is possible several times.
Yes, storage at 2-8° degrees.
Yes, TOXAVIT is an approved medicinal product; the approval was extended by the BfArM in September 2004 in the course of subsequent approval.
TOXAVIT is an approved medicinal product and is of course still available.
TOXAVIT is neither prohibited nor obsolete, but its use is restricted to cases in which, for example, vital extirpation is not possible (see information in the instructions for use and specialist information under “Indications for use”).
Occasionally, the lid of the tamper-evident closure may lift slightly after removing the guarantee ring by slightly relaxing the plastic. However, the jar is still leak-proof and stability is in no way impaired.
In general, 20 – max. 25 mg TOXAVIT is applied. This corresponds to a pellet about the size of a pinhead.
TOXAVIT must be applied without pressure and in contact with the pulp tissue and covered with a cotton swab.
A high-quality occlusion and marginal seal of the cavity is absolutely essential during the application period.
TOXAVIT must not be used if there is a perforation.
Any contact of the paraformaldehyde-containing TOXAVIT paste with the surrounding soft tissue during insertion or when sealing the tooth by swelling must be avoided due to its highly corrosive and necrotizing effect.
The maximum lying time of 14 days before mortal extirpation should not be exceeded. If there is residual vitality, the application can be repeated, again observing the maximum lying time of 14 days.
In case of allergy to formaldehyde, lidocaine, metacresol and eugenol. TOXAVIT must also not be used in the presence of perforation.
There are insufficient data for the use of TOXAVIT in pregnant women, therefore caution is advised when using it during pregnancy.
There are insufficient data for the use of TOXAVIT in breastfeeding women, therefore caution should be exercised when using it.
Due to the assumed low systemic exposure of paraformaldehyde after topical application of TOXAVIT, no effects on pregnancy or the breastfed newborn or infant are to be expected.
TOXAVIT can be used with caution during pregnancy and in breastfeeding women.
No clinical studies on exposed pregnant women are available for TOXAVIT.
Animal studies do not indicate direct or indirect adverse effects on pregnancy, embryonic/fetal development, parturition or postnatal development (see information in the package leaflet under “Reproductive potential, pregnancy and lactation”).
Not recommended for deciduous teeth due to the wide apical foramen and the proximity to the permanent teeth.
A tight seal is required to prevent the paste from oozing out.
ID: Medicinal product (Registration number 6031118.00.00) TOXAVIT. Dental Paste. Active substances: Paraformaldehyde, lidocaine hydrochloride 1 H2O and metacresol (Ph.Eur.). 1 g paste contains active ingredients: 460 mg paraformaldehyde, 370 mg lidocaine hydrochloride 1 H2O and 45 mg metacresol (Ph.Eur.). List of excipients: Eugenol, glycerol and carbon fibres. Therapeutic indications: TOXAVIT is used to devitalize dental pulp in particular cases where endodontic surgical measures (e.g. vital extirpation) are not possible. Prior to use, it should be checked whether successful treatment might be able to be achieved using other, aldehyde-free procedures (e.g. anesthesia or bleeding control). Contraindications: Allergy to any of the active ingredients or any of the other ingredients. Undesirable effects: Uncommon: Upon extirpation of the pulp, occasional bleeding occurs at the apical site of detachment despite devitalization. Very rare: When used on milk teeth, damage to the dental germ of the subsequent adult tooth may occur during the early stages of development (before mineralisation is complete) in extremely rare cases. Frequency not known: Following application to the exposed pulp cavity, more or less severe pulpitis-like complaints occur. These are relieved through the addition of the local anaesthetic lidocaine hydrochloride to the paste. In the event of insufficient diffusion or inadequate release of formaldehyde, vital tissue fragments can remain in the canal and cause considerable pain. If formaldehyde extravasates from the apex or the furcation area or side canals or leaking filling edges, inflammation or necrosis of periapical tissue, surrounding bone or the gums may result. Systemic effects cannot be ruled out. There are no findings on this method of application and local carcinogenicity. Local and systemic allergic reactions are possible. Date of current information: 10/2021. lege artis Pharma GmbH + Co. KG, P. O. Box 60, D-72132 Dettenhausen.